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“Herb is the healing of a nation, alcohol is the destruction.” ~ Bob Marley

By Brigitte Mouchet

CBD, or cannabidiol, is one of over 400 chemical compounds derived from Cannabis Sativa, interestingly enough, one of the first plants cultivated by humans. As early as 4,000 B.C. in China, cannabis was cultivated for its fibers to manufacture strings, ropes, textiles, and even paper. In India, the medical use of cannabis probably started around 1000 years B.C. In the Western world, the discovery of cannabinoid receptors in the brain, and of the Endocannabinoid System in the 1990’s brought it to the forefront of the scientific research scene.

Today, its surge in popularity comes from the fact that it offers significant medical benefits, without making people feel high. And those benefits are quite extraordinary: from thinking clearly to preventing most diseases. In spite of this, most health care practitioners don’t know much about CBD or hemp oil—hemp being a cannabis variety cultivated for its high CBD content and extremely low THC. Although CBD’s legal and regulatory status is still ambiguous, hemp-derived CBD products can be purchased in the US, which is still not the case with marijuana-derived CBD products.

My interview with Dr. Robban Sica, an expert in Integrative Medicine, provides an overview of the health and wellness benefits of hemp oil as well as recommendations on how to choose a hemp oil product safely and for maximum efficiency. Join me for an enlightening discussion that could possibly change your life!

Our hero for this week is Dr. Raphael Mechoulam, an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel. Mechoulam is best known for his work (together with Y. Gaoni) in the isolation, structure elucidation and total synthesis of Δ9-tetrahydrocannabinol, the main active principle of cannabis and for the isolation and the identification of the endogenous cannabinoids anandamide from the brain and 2-arachidonoyl glycerol (2-AG) from peripheral organs together with his students, postdocs and collaborators.

This week in Let’s Go to the Movies we recommend “The Scientist” a documentary that traces the story of Dr. Raphael Mechoulam from his early days as a child of the Holocaust in Bulgaria, through his immigration to Israel, and his career as the chief investigator into the chemistry and biology of the world’s most misunderstood plant: cannabis.

As this is the last week of the month, there is no Money & Markets commentary. Post your questions for Catherine at Subscriber Input or at the commentary for her Money & Markets on February 7, 2019.

Talk to you Thursday!

Related Websites:

Healoha: Your Wellness Network

The Solari Wellness Series

Project CBD: This website is useful if you want to stay on top of the latest news, science and research about CBD.

Where to find high-quality hemp oil products:

CTFO

Dr. Sica and I both recommend the 10x pure product from CTFO, which I recently tried. I did feel a big difference compared to other hemp oil products from CTFO that I had been using. Everybody is different though and therefore will have a different experience with hemp oil products. You will need to experiment to see how it works for you.

Additional reading:

1. CBD Nature’s Supplement: This document discusses the main benefits of CBD.

2. The Emperor Wears No Clothes (by Weedshop): Everything you’ve always wanted to know about the history and use of Cannabis over the years.

3. Introduction to the Endocannabinoid System by Dr. Dustin Sulak, DO

66 Comments

  1. Though I am by no means a puritan or prohibitionist, I view pot legalization as very much a mixed baggie. People in our world are dopier than ever with their noses stuck in their devices, their minds locked into corporate media-driven paradigms and their commonsense hijacked by brainwashed pipe-dreams of social justice. I have seen examples of drunk and stoned vehicle operators causing fatal incidents (and texting or other distractions wouldn’t help the matter). More intoxicants do not appear to be propitious.

    I do recognize, however that there are numerous legitimate uses of hemp (not least of which, it makes the best rope), including medicinal value in pain management and health promotion. I am also going to hang it out that it should be alright to use it sensibly for no reason beyond recreation.

    But there are sinister aspects of cannabinoids, which fall into Catherine’s “Traffic Tickets for White Collar Workers” category. Most professionals are regulated by strictures to ensure their non-usage of popular intoxicants. Loss of license (professional and/ or driving) and livelihood are potential outcomes for DUI convictions or drug test failures. It’s not clear how public health, safety and welfare could be assured by a relaxation of those strictures.

    For those of us who came of age in the hippie era, marijuana use was more of a sideshow than a fetish as it seems to have become today. Most were reasonable in their use of it and law enforcement, though quite a bit stricter overall in those days than now, were mainly tolerant of it. I am concerned that irresponsible people tend to ruin good things for everyone. If the parlance of those halcyon days could be enacted, it would be cool if everyone was cool about the stuff. That would include not having to be stoned all the time just because it is legal. If we wish a better world, as always, we must be a better people.

    2. Hi John,

      Thank you for your comment! We did address some of those issues during the interview with Dr. Sica. Let’s see if that helps. Also, please note that the focus of the interview is on hemp oil, not marijuana! Brigitte

      1. I listened to this interview with interest.
        I use canibis oil for neuropathy pain.
        It is legal to buy in California..from pot shops…I have a problem with the fact there is no real regulation on the quality you are getting.
        I don’t eat produce grown in California unless it’s CERTIFIED ORGANIC.
        There is no way of knowing for sure you’re not getting GMO or pesticides.

        1. Hi Diane,

          Thank you for your comment and interest! I agree, it is hard to know what quality you are getting with a lot of products whether food or supplements, that’s why Dr. Sica recommends to only buy hemp oil products that are organic. Of course certified organic is even better. FYI, CTFO gets their hemp from Colorado. Always do your own research on the companies you are buying from, call their customer service and see how willing they are to answer your questions. Best, Brigitte

    3. The warning I saw about high THC content in legalized marijuana was quite sobering. I am wondering what the real deal on all of this is. If anyone has good sources on the underside of what is happening, please post!

      1. There are, or were, many strains of Cannabis one hundred years ago (it was a roadside weed). It is not surprising that during Cannabis prohibition repeated selection for strains with higher THC resulted, after all they are selling the ‘high’. Pay more for better? Now again plant breeding is in high gear this time to select for higher CBD compounds concentration.

  2. Though I am by no means a puritan or prohibitionist, I view pot legalization as very much a mixed baggie. People in our world are dopier than ever with their noses stuck in their devices, their minds locked into corporate media-driven paradigms and their commonsense hijacked by brainwashed pipe-dreams of social justice. I have seen examples of drunk and stoned vehicle operators causing fatal incidents (and texting or other distractions wouldn’t help the matter). More intoxicants do not appear to be propitious.

    I do recognize, however that there are numerous legitimate uses of hemp (not least of which, it makes the best rope), including medicinal value in pain management and health promotion. I am also going to hang it out that it should be alright to use it sensibly for no reason beyond recreation.

    But there are sinister aspects of cannabinoids, which fall into Catherine’s “Traffic Tickets for White Collar Workers” category. Most professionals are regulated by strictures to ensure their non-usage of popular intoxicants. Loss of license (professional and/ or driving) and livelihood are potential outcomes for DUI convictions or drug test failures. It’s not clear how public health, safety and welfare could be assured by a relaxation of those strictures.

    For those of us who came of age in the hippie era, marijuana use was more of a sideshow than a fetish as it seems to have become today. Most were reasonable in their use of it and law enforcement, though quite a bit stricter overall in those days than now, were mainly tolerant of it. I am concerned that irresponsible people tend to ruin good things for everyone. If the parlance of those halcyon days could be enacted, it would be cool if everyone was cool about the stuff. That would include not having to be stoned all the time just because it is legal. If we wish a better world, as always, we must be a better people.

    2. Hi John,

      Thank you for your comment! We did address some of those issues during the interview with Dr. Sica. Let’s see if that helps. Also, please note that the focus of the interview is on hemp oil, not marijuana! Brigitte

      1. I listened to this interview with interest.
        I use canibis oil for neuropathy pain.
        It is legal to buy in California..from pot shops…I have a problem with the fact there is no real regulation on the quality you are getting.
        I don’t eat produce grown in California unless it’s CERTIFIED ORGANIC.
        There is no way of knowing for sure you’re not getting GMO or pesticides.

        1. Hi Diane,

          Thank you for your comment and interest! I agree, it is hard to know what quality you are getting with a lot of products whether food or supplements, that’s why Dr. Sica recommends to only buy hemp oil products that are organic. Of course certified organic is even better. FYI, CTFO gets their hemp from Colorado. Always do your own research on the companies you are buying from, call their customer service and see how willing they are to answer your questions. Best, Brigitte

    3. The warning I saw about high THC content in legalized marijuana was quite sobering. I am wondering what the real deal on all of this is. If anyone has good sources on the underside of what is happening, please post!

      1. There are, or were, many strains of Cannabis one hundred years ago (it was a roadside weed). It is not surprising that during Cannabis prohibition repeated selection for strains with higher THC resulted, after all they are selling the ‘high’. Pay more for better? Now again plant breeding is in high gear this time to select for higher CBD compounds concentration.

  3. What is the name of the brand that Dr. Sica recommends, was organic cbd oil “Penex Pure” … the name is not clear from the audio. … oh … now I see from the text above it was ” 10x pure” … thank you.

  4. What is the name of the brand that Dr. Sica recommends, was organic cbd oil “Penex Pure” … the name is not clear from the audio. … oh … now I see from the text above it was ” 10x pure” … thank you.

  5. she is right.

    cannabinoids are retrograde signaling molecules in neurons and message pre-synaptic cells..

    there is an order of magnitude more cannabinoid receptors in most tissues than opioid receptors.

    unlike opioid receptors, however, the cannabinoid receptor density on the respiratory center of the brain stem is minimal.

    major endogenous cannabinoid ligand agonists are derived from fatty acids in cell membranes, predominantly arachidonic acid (the same thing that derives proinflmmatory cytokines inhibited by NSAIDS!), and, consistent with retrograde signaling, i do believe the endocannabinoid system evolved as a negative feedback check on runaway proinflammatory signaling.

    cannabinoid tolerance does indeed partially cross-tolerate with opioids.

    cannabinoinds facilitate LTD – commonly known as the process of forgetting – and the opposite of LTP. as such they help with fear extinction.

    remember, what we remember is just as important as what we dont!

    THC is a partial CB1 agonist (not a full agonist) and consistently impairs all aspects of learning and working memory, though tolerance generally develops with prolonged administration.

    use before 17 can persistently alter neurodevelopmental trajectory and must be avoided as it leads to long term deficits in verbal memory.

    chronic use of cannabis in adulthood weakens (likely reversibly) frontal cortical white matter integrity but high CBD in plants likely attenuates this.

    it takes as long as 3 months to fully reverse cognitive impairment from chronic cannabis use in adults.

    the plant has been called a ‘treasure-trove’ in the medical literature.

      1. There is always a dark side to these things. So I am curious as to whether some of the products are targeting the people who will not take Prozac, etc. Want to cut people off from the divine. Get them have a passive response to fascism. Ease their learning to resonate with machines instead of living things.

  6. she is right.

    cannabinoids are retrograde signaling molecules in neurons and message pre-synaptic cells..

    there is an order of magnitude more cannabinoid receptors in most tissues than opioid receptors.

    unlike opioid receptors, however, the cannabinoid receptor density on the respiratory center of the brain stem is minimal.

    major endogenous cannabinoid ligand agonists are derived from fatty acids in cell membranes, predominantly arachidonic acid (the same thing that derives proinflmmatory cytokines inhibited by NSAIDS!), and, consistent with retrograde signaling, i do believe the endocannabinoid system evolved as a negative feedback check on runaway proinflammatory signaling.

    cannabinoid tolerance does indeed partially cross-tolerate with opioids.

    cannabinoinds facilitate LTD – commonly known as the process of forgetting – and the opposite of LTP. as such they help with fear extinction.

    remember, what we remember is just as important as what we dont!

    THC is a partial CB1 agonist (not a full agonist) and consistently impairs all aspects of learning and working memory, though tolerance generally develops with prolonged administration.

    use before 17 can persistently alter neurodevelopmental trajectory and must be avoided as it leads to long term deficits in verbal memory.

    chronic use of cannabis in adulthood weakens (likely reversibly) frontal cortical white matter integrity but high CBD in plants likely attenuates this.

    it takes as long as 3 months to fully reverse cognitive impairment from chronic cannabis use in adults.

    the plant has been called a ‘treasure-trove’ in the medical literature.

      1. There is always a dark side to these things. So I am curious as to whether some of the products are targeting the people who will not take Prozac, etc. Want to cut people off from the divine. Get them have a passive response to fascism. Ease their learning to resonate with machines instead of living things.

  7. Before the recent Farm Bill passed making hemp once again legal, all Cannabis was on the Drug Enforcement Agency Schedule One list –drugs with “no known medical uses”– resulting in black markets, drug wars, violence and wasted lives. All the while, another US government agency, the Department of Health and Human Services holds US Patent #6,630,507 –cannabinoids for the prevention and treatment of diseases including auto-immune disorders, stroke, trauma, Parkinson’s, Alzheimer’s and dementia. The Patent Office granted GW Pharmaceuticals multiple cannabis patents: #8,790,719, #9,017,737, #9,168,278 and #9,205,063, for treatments of prostate, breast and colon cancers, neural degeneration, psychotic disorders, and as an appetite suppressant. More patents for GW Pharmaceuticals are pending. A descriptive name for this is hypocrisy.

    1. And this just to start off the whole sordid history of the Drug Enforcement Agency DEA: “Reefer makes darkies think they’re as good as white men.” -Harry J. Anslinger, Commissioner of the U.S. Federal Bureau of Narcotics, 1930

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